Chiral Separations by Capillary Electrophoresis

This volume provides a comprehensive, up-to-date overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. It discusses the important current, as well as several emerging, chiral selectors used in capillary electrophoresis. The book reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. It also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available.

Ann Van Eeckhaut is a postdoctoral researcher in the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium. Yvette Michotte is the head of the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium.

Pharmacological Importance of Chiral Separations. Principles of Chiral Separations by Free-Solution Electrophoresis. Cyclodextrin-Mediated Chiral Separations. Factors Influencing Cyclodextrin-Mediated Chiral Separations. Macrocyclic Antibiotics as Chiral Selectors. Chiral Separations Using Proteins and Peptides as Chiral Selectors. Chiral Ligand Exchange Capillary Electrophoresis. Chiral Separations by Micellar Electrokinetic Chromatography. Chiral Microemulsion Electrokinetic Chromatography. Chiral Separations in Nonaqueous Media. Quantitative Analysis in Pharmaceutical Analysis. Analysis of Chiral Drugs in Body Fluids. Chiral Capillary Electrophoresis-Mass Spectrometry. Enantioseparations by Capillary Electrochromatography. Recent Applications in Capillary Electrochromatography. Chiral Separations with Microchip Technology. Index.