Compendium of 3D Bioprinting Technology

3D bioprinting is an emerging innovative technology that involves the fabrication of essential 3D functional biomedical constructs by combining cells and biomaterials with vital growth and differentiation factors. It aims to replicate the natural tissue milieu and holds great promise in fields like tissue engineering, regenerative medicine, drug development and testing, precision medicine, etc. 3D bioprinted disease-specific models help to study, screen the treatment methods and understand the mechanism of action. In personalized medicine, patient-specific tissue and organ constructs can be developed for specific surgeries and treatments tailored to a patient's unique anatomy and genetics. 3D functional tissue construct addresses the problem of organ shortage as it lowers the risk of rejection of tissues and organs. The technique also replaces the need to experiment on animals and improves the accuracy of pre-clinical studies to test the safety and efficacy of new drugs in bioprinted tissues. This book provides comprehensive coverage of the application of 3D bioprinting technology. It is a collection of contributions by experts with cutting-edge know-how. The book is meant for medical practitioners, pharma companies, CROs, product developers, students, researchers, academicians, policymakers and practitioners.

Dr. Mohanan is a Fellow of the National Academy of Science, India and Royal Society of Biologists, UK. He was a JSPS Postdoctoral Fellow at the University of Tsukuba, Japan in the field of Neurotoxicity. As a toxicologist, he has been intimately associated with all the medical devices/technologies developed at SCTIMST (Govt. of India). Currently he heads both the Division of Toxicology and Dept. of Applied Biology. Dr. Mohanan is a member in the Empowered Committee on the 'Rapid Response Regulatory Framework for COVID-19 to deal with applications for development of vaccines, diagnostics, prophylactics and therapeutics and an expert member in the statutory Committee, RCGM, DBT, New Delhi. Mohanan is also serving as an expert member at the DST, SERB, DBT, ICMR, CSIR and FSSAI Scientific committees. He is an Expert member at the Joint Food and Agriculture Organization of the United Nations and the World Health Organization (JECFA), USA. Mohanan is a member in the Scientific Advisory Committee of ICMR-NARFBR, Hyderabad. He is a Visiting Professor and Visiting Researcher at Toyo University, Japan and a Certified Biological Safety Specialist. Mohanan is an Adjunct Professor at the Indian Institute of Technology, Hyderabad and Jamia Hamdard University, New Delhi. He received lifetime achievement award from the Society of Toxicology India, for his outstanding contribution in toxicology. The development of Human-on-a-chip is a new mega project, apart from several other externally funded research projects. Patented an ELISA kit for the measurement of pyrogenicity. Mohanan made significant contributions for the development of medical device regulations in India. He received certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India for his contribution to India getting full adherent status on GLP from OECD. He has authored more than 300 publications, edited 10 books, 5 patent filed and 3 design registrations. Presently he is the Secretary General, Society of Toxicology, India and Vice President, Kerala Academy of Sciences, India.

Preface. PART I: OVERVIEW. The History of 3D Bioprinting. Overview of 3D Bioprinting Technology. Strategies in 3D Bioprinting. Recent Advances in 3D Bioprinting. Futuristic Application of 3D Bioprinted Organs. Ethics Associated with 3D-Printed Organs. Challenges in 3D-Bioprinting Techniques. Advantages and Disadvantages of 3D Bioprinting. PART II: BIOPRINTING OF MATERIALS. Materials for 3D Bioprinting. Bioinks for 3D Bioprinting. Safety and Toxicity of 3D Printed Medical Products. PART III: MEDICAL APPLICATIONS OF BIOPRINTING. 3D Printing of Biomaterials. 3D Printing in Prosthetic Devices. 3D Printing in Medicine. 3D Printing in Food Technology. 3D Bioprinted Scaffolds. 3D Bioprinting and Tissue Engineering. 3D Printing of Composite Materials for Bone Tissue Engineering. 3D Bioprinted Organs for Toxicity Evaluation. 3D Bioprinting in Vascular Tissue Engineering. 3D Bioprinting of Liver Tissue. 3D Bioprinting Lung Tissue. 3D Bioprinting Skin Tissue. Building Better Faces: The 3D Bioprinting Breakthrough in Maxillofacial Surgery. 3D Bioprinting of Cartilage. 3D-Bioprinting of Eye. Towards 3D-Bioprinting the Artificial Ovary. 3D Bioprinting of Kidney. Index.