Coulometric Electrode Array Detectors for HPLC

This sixth volume in the book series Progress in HPLC-HPCE examines the enhancement of high- performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) --- the coulometric array detection --- from its initial, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100% efficient and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector.

I.H. Acworth, M. Naoi, Hasan Parvez, S. Parvez

Preface, AN INTRODUCTION TO HPLC BASED ELECTROCHEMICAL DETECTION FROM SINGLE ELECTRODE TO MULTI-ELECTRODE ARRAYS; THEORETICAL AND APPLIED ASPECTS; HPLC WITH ELECTRODE ARRAY DETECTION AND ITS APPLICATION IN ANALYTICAL FOOD CHEMISTRY; THE MEASUREMENT OF MARKERS OF OXIDATIVE DAMAGE, ANTI-OXIDANTS AND RELATED COMPOUNDS USING HPLC AND COULOMETRIC ARRAY ANALYSIS; CEA S GENERATION OF LARGE MULTI-PARAMETER METABOLIC DATABASES FOR DETERMINING CATEGORICAL PROCESS INVOLVEMENT OF BIOLOGICAL MOLECULES; THE APPLICTAION OF EC-H PLC TO THE ANALYSIS OF INSECT BIOGENIC AMINES; A PHYLOGENETIC ANALYSIS OF BIOGENIC MONOAMINES IN THE CENTRAL NERVOUS SYSTEMS OF VARIOUS ORGANISMS AND APPLICATION TO THE FIELDS OF MEDICAL BIOCHEMISTRY; MULTI-COMPONENT QUANTITATIONS OF MONOAMINES AND RELATED COMPOUNDS IN BIOLOGICAL FLUIDS AND CNS TISSUES BY HPLC COUPLED WITH MULTI-ELECTRODE ELECTROCHEMICAL DETECTION; THE APPLICATIO PF THE MUTLI-ELECTRODE DETECTION SYSTEM TO NEUROCHEMISTRY: IN VIVOMICRODIALYSIS STUDIES; Part Contents