Advances in Friedel-Crafts Acylation Reactions

Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. This book focuses on how to make this reaction more economically and environmentally friendly by using green acylating conditions, minimizing the formation of waste and decreasing production costs. Incorporating examples of all acid-catalyzed Friedel-Crafts acylation reactions, the text considers classic Lewis and Brönsted acid types along with more innovative and advanced multicomponent superacid catalysts. The book emphasizes the major industrial applications, providing a critical assessment of the differences, advantages, and disadvantages of homogeneous and heterogeneous catalysis.

Giovanni Sartori is the Head of the "Clean Synthetic Methodologies Groups" of the University of Parma in Italy. His research interests include all aspects of the heterogeneous catalysis applied to the fine chemicals and pharmaceuticals production with particular attention to the preparation and use of supported organic (chiral) catalysts. Raimondo Maggi is an Associate Professor of Organic Chemistry at the University of Parma. His research interests include the preparation and use of heterogeneous (chiral) catalysts for the environmentally friendly synthesis of fine chemicals and pharmaceuticals.

Introduction and Scope. Stoichiometric Acylations. Catalytic Homogeneous Acylations. Catalytic Heterogeneous Acylations. Direct Phenol Acylation - Fries Rearrangement.