Synthetic Sequences in Organic Chemistry

Drawing on the vast amount of experience the author has gained from working in industrial and university laboratories, this continuation of the author's previous collection of excerpt reports contains essential details from literature relevant to the synthesis of compounds on a milligram to kilogram scale. A number of the compounds that have eluded efficient preparation in the past are now presented. Material which will improve any chemist's existing synthetic methodology can be found here. Each of the chapters illustrates a novel application of syntheses selected from twenty-first-century literature. Key Features: - Selected classical and contemporary advances in synthetic organic chemistry are described in a condensed graphics-oriented format. - Recent reports in methodology, strategy, and total synthesis are presented with a minimum of background and experimental detail. - The graphical table of contents, chapter outlines and enhanced index facilitate the search for specific content and material of interest. - The target readership is graduate students, chemists new to the specialty of organic synthesis, and professionals reviewing the current literature. - The author's experience is in medicinal chemistry, organometallics, polymer preparation, and synthesis scale-up for commercial applications.

Jerome Zoeller graduated from Rensselaer Polytechnic Institute, USA, with a B.S. in Chemistry and began work at the Rohm & Haas Co. in applications and pro-cess development with acrylic polymers. Graduate study followed at the University of Texas, USA, with research concentration in physical organic chemistry. Upon completing the Ph.D. program, he went on for two years as a Postdoctoral Research Fellow in the use of organometallics in synthetic and structural studies. At the Southwest Foundation for Research and Education he developed preparative methods for cortisol analogs, and their use in affinity chromatography and primate brain research. In this decade he lectured at Trinity University, USA. A change in career occurred in which he studied Fuel Science at The Pennsylvania State University, USA. This specialty was pursued at Texas A&M University, USA, in the use of specialized oxidative transformations in studies of fossil fuel structure. Upon retirement he moved to a startup pharma company, Targacept Inc., for synthetic work on nicotinic acetylcholine esterase ligands of potential neurological activity. Upon moving to Texas, he was prompted to compile some of the synthetic sequences displayed in the twenty-first century literature, for this book.

About The Author. Introduction. Chapter 1: Alternate Routes. Chapter 2: Enatiomers and Diasteriomers. Chapter 3: Structural Moieties. Chapter 4: Single Reactions. Chapter 5: Name Reactions. Chapter 6: Natural Products. Chapter 7: Drug Development. Index