Membrane Separations in Biotechnology

This text details the relationship between membrane technology and bioprocesses, discussing applications. This second edition refines and optimizes key features of the first edition - and features new illustrative case studies. The book examines advantages and disadvantages of using standard and new membrane technologies; analyzes a wide range of applications, including cell culture harvesting and product and process validation techniques; and more.

William K. Wang

Protein transport in ultrafiltration hollow-fibre bioreactors for mammalian cell culture; vortex flow filtration for cell separation in bioreactor operations; crossflow membrane filtration of fermentation broth; cross-flow microfiltration with backpulsing; the effects of different membrane modular systems on the performance of cross flow filtration of picha pastoris suspensions; filter applications in product recovery processes; ultrafiltration membranes in the vaccine industry; protein purification by affinity ultrafiltration; process development for the isolation of a recombinant immunofusion protein using a membrane adsorber; high performance tangential flow filtration; virus removal by ultrafiltration - a case study with diaspirin crosslinked haemoglobin (DCLHb); scale up and virus clearance studies on viral filtration in monoclonal antibody manufacture; virus removal filtration.