Supercritical Fluid Chromatography and Extraction

Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Recent, significant improvements in instrumentation have rekindled interest in SFC and have enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its potential beyond traditional liquid chromatography, yet many of its capabilities remain underappreciated. Supercritical Fluid Chromatography and Extraction explores contemporary supercritical fluid chromatography and extraction and how it should be implemented in laboratory science for analysis, isolation, and production.New to This EditionThis new edition details recent advances and applications of supercritical fluids in sample prep, instrumental analysis, and process-scale, including SFE, making it a comprehensive resource for both techniques. Further enhancements to this edition include: - Expanded section on SFC theory to include gradient elution - A new chapter on general detectors for SFC - Enhanced method development coverage, with focus on gradient elution practices - Includes multidimensional SFC, SFC × SFC, and LC-SFC - Features comprehensive information on accelerated solvents, comparing solvent and extraction techniques. - Highlights environmental monitoring and analysis applications of SFE. Widely used in the food industry for decades, SFE is now expanding into new fields. Supercritical Fluid Chromatography and Extraction, Second Edition serves as a valuable resource for chemical engineers, chemists, researchers, students, and academics working with supercritical fluids at preparative and process scales. It's also an ideal introduction for newcomers to SFC and SFE. - Covers method development for SFC and SFE across instrument platforms and process scale for both techniques - Combines comprehensive coverage of both techniques in one volume - Edited and authored by leading chromatography and extraction experts - Contains over 200 figures and tables for clarity and key concept retention - Showcases applications in environmental monitoring, food, natural products, forensic science, petrochemicals, pharmaceuticals, and bioanalysis

1. Core concepts and milestones in the exploitation of supercritical fluids in separation science2. Theory of supercritical fluid chromatography3. Stationary phases for supercritical fluid chromatography4. Stationary phases for the separation of stereoisomers by supercritical fluid chromatography5. Co-solvents and mobile phase additives in supercritical fluid chromatography6. Method development in supercritical fluid chromatography7. Instrument platforms for supercritical fluid chromatography8. General detectors for supercritical fluid chromatography9. Mass spectrometric detection in supercritical fluid chromatography10. Multidimensional supercritical fluid chromatography11. Method validation in supercritical fluid chromatography12. Sample preparation for supercritical fluid chromatography13. Supercritical fluid chromatography of amino acids and peptides14. Supercritical fluid chromatography of lipids15. Supercritical fluid chromatography of stereoisomers16. Applications of supercritical fluid chromatography in environmental analysis17. Applications of supercritical fluid chromatography in food analysis18. Applications of supercritical fluid chromatography in forensic analysis19. Applications of supercritical fluid chromatography in natural product analysis20. Applications of supercritical fluid chromatography in the analysis of petrochemicals21. Applications of supercritical fluid chromatography in the pharmaceutical industry22. Applications of supercritical fluid chromatography in bioanalysis23. Theory for preparative supercritical fluid chromatography24. Instrument platforms for preparative and process scale supercritical fluid chromatography25. Applications of preparative and process scale supercritical fluid chromatography in the pharmaceutical industry26. Applications of preparative and process scale supercritical fluid chromatography of natural products27. Core concepts and fundamentals of supercritical fluid extraction28. Instrument platforms for supercritical fluid extraction29. Pressurized hot-water and accelerated solvent extraction30. Supercritical fluid extraction of essential oils31. Supercritical fluid extraction of lipids and bio-oils32. Supercritical fluid extraction of agricultural products33. Supercritical fluid extraction of petroleum products34. Applications of Supercritical fluid extraction for environmental analysis