The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer

Exploring their role in the physiology of development and wound repair and pathophysiologies such as cancer, this book describes the importance of biological electric fields and their use as tools to influence tissue repair and regeneration. It also discusses the role of bioelectricity in cancer progression and the potential for bioelectricity-based therapies to target both the tumor and metastatic cancer cells. It demonstrates the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation.

Christine E. Pullar is a lecturer at the University of Leicester in the UK. She received her Ph.D. in immune cell signal transduction from the University of Sheffield, UK. The Wellcome Trust, the Medical Research Council, and the British Skin Foundation currently fund her lab. Her work has a strong translational flair, including projects that aim to promote healing in chronic wounds and reduce wound scarring, and she hold several patents in this area. She has delivered invited lectures at more than 20 international meetings and is active in mentoring young scientists within the research community.

Measuring Endogenous Electric Fields. Investigation Systems to Study the Biological Effects of Weak Physiological Electric Fields. Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm. Stem Cell Physiological Responses to Noninvasive Electrical Stimulation. Electrical Signals Control Corneal Epithelial Cell Physiology and Wound Repair. Physiological Electric Fields Can Direct Keratinocyte Migration and Promote Healing in Chronic Wounds. Electrical Control of Angiogenesis. Inflammatory Cell Electrotaxis. Effects of DC Electric Fields on Migration of Cells of the Musculoskeletal System. Neuronal Growth Cone Guidance by Physiological DC Electric Fields. Can Applied Voltages Be Used to Produce Spinal Cord Regeneration and Recovery in Humans? Bioelectricty of Cancer: Voltage-Gated Ion Channels and Direct-Current Electric Fields.