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The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies.
Warren H. Finlay has been a Professor of Mechanical Engineering at the University of Alberta since 1987 and is the founding Director of the Aerosol Research Laboratory of Alberta (ARLA). He has published more than 180 highly respected journal articles and is the Editor-in-Chief of Aerosol Science and Technology. He holds the Canada Research Chair in Aerosol Mechanics and the title of Distinguished Professor at the University of Alberta. He has been inducted as a Fellow of the Royal Society of Canada, and is the recipient of the Career Achievement Award from the International Society for Aerosols in Medicine, the Charles G. Thiel Award from Respiratory Drug Delivery, as well as lifetime designations as a Fellow of the Engineering Institute of Canada and the American Association for Aerosol Research, among other academic awards for outstanding achievement. Dr. Finlay received his Ph.D. from Stanford University in 1987.
1. Introduction 2. Particle Size Distributions 3. Motion of a Single Aerosol Particle in a Fluid 4. Particle Size Changes Due to Evaporation or Condensation 5. Introduction to the Respiratory Tract 6. Fluid Dynamics in the Respiratory Tract 7. Particle Deposition in the Respiratory Tract 8. Nebulizers 9. Dry Powder Inhalers 10. Metered Dose Propellant Inhalers
