Handbook for Chemical Process Research and Development, Second Edition

This handbook is designed to provide readers with an unprecedented strategy approach to mechanism-guided process development, helping process chemists and students in industrial chemistry develop chemical processes efficiently. The latest edition addresses common process issues such as safety, cost, robustness, and environmental impact.

Dr Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow in Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate professor in Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (Now becomes Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Sr. research associate in Department of Chemistry, Texas Tech University, Lubbock, Texas 2001 - 2005. Dr Wenyi Zhao then moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.

1. Reaction solvent selection 2. Reagent selection 3. Various reagent surrogates 4. Modes of reagent addition -control of impurity formation 5. Process optimization with additives 6. Process optimization of catalytic reactions 7. Process optimization of problematic reactions 8. Hazards of oxidation and reduction reactions 9. Other hazardous reactions 10. Hazardous reagents 11. Grignard reagent and related reactions 12. Challenging reaction intermediates 13. Protecting groups 14. Telescope approach 15. Design of new synthetic route 16. Stereochemistry 17. Various quenching strategies 18. Various isolation and purification strategies 19. Methods for residual metal removal 20. Methods for impurity removal 21. Pharmaceutical salts 22. Solid form