Cell Culture Bioprocess Engineering, Second Edition

This reference guide is designed for industrial practitioners of mammalian cell cultivation for the production of biologics. This work is a culmination of two decades of accumulated expertise, practical know-how and best practices in cell culture technology. The Second Edition consists of major updates to all relevant topics.

Wei-Shou Hu is a Distinguished McKnight University Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota. His education and research efforts focus on bioprocess engineering and systems biotechnology. He is the author of Engineering Principles in Biotechnology and co-author of the textbook Bioseparations. For over three decades, he has been an active member in the cell culture bioprocess community. He is the founder of both a popular training course in cell culture bioprocess technology and an important cell technology conference that served as an important forum for cell technology advancement.

Preface; 1. Overview of Cell Culture Processes; 2. Cell Biology for Bioprocessing; 3. Cell Physiology; 4. Product Quality and Process; 5. Stoichiometry and the Kinetics of Cell Cultivation; 6. Cell Line Development; 7. Medium Design for Cell Culture Processing; 8. Cell Culture Bioreactors; 9. Fed-Batch Culture Processes; 10. Continuous Cell Culture Processes; 11. Oxygen Transfer in Cell Culture Bioreactors; 12. Scaling Up and Scaling Down for Cell Culture Bioreactors; Appendices: Cell Culture Process Data Analysis